Quite a while ago now, I mentioned the Close the Airlock! Traveller podcast. That ended sometime in 2013, I think, and there was radio silence for a long time. Possibly due to them doing short-term gaming rather than epic campaigns? Not sure. Eventually, though, the group have resumed podcasting with a 5e D&D campaign that's supposed to focus on grey-morality urban intrigue, and a party of... let's say, "protagonists" rather than "heroes", not evil but very much looking out for their own interests.
I'm up to Episode 12 so far and having a lot of fun; it's fairly ambient play, so great for listening to as I get on with other stuff. Although at least one person is Skyping in, there's not many issues with people speaking over each other. There's some background crackle at times, but I haven't found it a problem (although of course, better audio is always welcome).
They're taking this pretty seriously (not the game, but the podcast) so there's a blog up at https://downfalldnd.wordpress.com/for-new-listeners/ as well as copies of the maps they use, an extensive players' guide if you want to know more about the homebrew world, and even a substantial GM's guide that you can pick up by donating. Obviously not for everyone (I don't have one, for a start) but if you're interested in running something similar or just in porting the setting, it might be a good option.